Matsumoto S, Kinoshita Y, Fukuda H, Waki S, Asahara M, Matsushima Y, Kawanami C, Fujimori T, Chiba T
Department of Medicine, Kobe University School of Medicine.
Intern Med. 1996 Dec;35(12):961-5. doi: 10.2169/internalmedicine.35.961.
We report a case of Mediterranean lymphoma treated with antibiotics. A 74-year-old woman visited the hospital due to abdominal pain. Endoscopic examination showed erosions and ulcerations on duodenal mucosa. Biopsy specimens histologically revealed massive infiltration of small-sized lymphocytes and plasma cells in subepithelial mucosa. Immunoperoxidase staining showed that the infiltrating cells were positively stained with anti-alpha heavy chain. Serum IgA concentration was elevated and immunoelectrophoresis of the serum demonstrated monoclonal protein composed of alpha heavy chain. During the antibiotic treatment her symptoms disappeared and serum IgA concentration was normalized. Endoscopic examination also showed healing of the duodenal ulceration. The similarities between Mediterranean lymphoma and gastric mucosa-associated lymphoid tissue (MALT) type lymphoma, both of which may be related to bacterial infection and can be treated with antibiotics, are discussed in this report.
我们报告了一例用抗生素治疗的地中海淋巴瘤病例。一名74岁女性因腹痛前来就诊。内镜检查显示十二指肠黏膜有糜烂和溃疡。活检标本组织学显示上皮下黏膜有大量小淋巴细胞和浆细胞浸润。免疫过氧化物酶染色显示浸润细胞抗α重链呈阳性染色。血清IgA浓度升高，血清免疫电泳显示由α重链组成的单克隆蛋白。抗生素治疗期间，她的症状消失，血清IgA浓度恢复正常。内镜检查还显示十二指肠溃疡愈合。本报告讨论了地中海淋巴瘤与胃黏膜相关淋巴组织（MALT）型淋巴瘤之间的相似性，两者均可能与细菌感染有关且可用抗生素治疗。
