Voss A, Kluytmans J A, Koeleman J G, Spanjaard L, Vandenbroucke-Grauls C M, Verbrugh H A, Vos M C, Weersink A Y, Hoogkamp-Korstanje J A, Meis J F
University of Hospital Nijmegen, Department of Medical Microbiology, Nijmegen, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1996 Dec;15(12):909-12. doi: 10.1007/BF01690507.
The aim of this study was to identify retrospectively trends in fungal bloodstream infections in The Netherlands in the period from 1987 to 1995. Results of over 395,000 blood cultures from five Dutch university hospitals were evaluated. Overall, there were more than 12 million patient days of care during the nine-year study period. The rate of candidemia doubled in the study period, reaching an incidence of 0.71 episodes per 10,000 patient days in 1995. The general increase in candidemia was paralleled by an increase in non-Candida albicans bloodstream infections, mainly due to Candida glabrata. However, more than 60% of the infections were caused by Candida albicans. Fluconazole-resistant species such as Candida krusei did not emerge during the study period. The increasing rate of candidemia found in Dutch university hospitals is similar to the trend observed in the USA, but the rate is lower and the increase is less pronounced.
本研究的目的是回顾性确定1987年至1995年期间荷兰真菌血流感染的趋势。对荷兰五所大学医院超过39.5万份血培养结果进行了评估。在为期九年的研究期间，总的护理患者天数超过1200万天。在研究期间，念珠菌血症发生率翻倍，1995年达到每10000个患者日0.71例的发病率。念珠菌血症的总体增加与非白色念珠菌血流感染的增加同时出现，主要是由于光滑念珠菌。然而，超过60%的感染是由白色念珠菌引起的。在研究期间，未出现对氟康唑耐药的菌种，如克柔念珠菌。荷兰大学医院发现的念珠菌血症发生率上升趋势与美国观察到的趋势相似，但发生率较低且上升幅度较小。
