单纯疱疹病毒1型感染细胞中凋亡性DNA片段化的抑制
Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells.
作者信息
Koyama A H, Miwa Y
机构信息
Department of Virology, School of Medicine, The University of Tokushima, Japan.
出版信息
J Virol. 1997 Mar;71(3):2567-71. doi: 10.1128/JVI.71.3.2567-2571.1997.
Abstract
HEp-2 cells underwent apoptosis when the cells were incubated in medium containing sorbitol. Infection with herpes simplex virus type 1 (HSV-1) prior to the sorbitol treatment suppressed this apoptosis completely, indicating that HSV-1 carries an antiapoptosis gene. In addition, HSV-1 multiplication was restricted in these apoptotic HEp-2 cells.
摘要
当HEp-2细胞在含有山梨醇的培养基中培养时，会发生凋亡。在山梨醇处理之前感染单纯疱疹病毒1型（HSV-1）可完全抑制这种凋亡，这表明HSV-1携带一种抗凋亡基因。此外，HSV-1在这些凋亡的HEp-2细胞中的增殖受到限制。
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