Bernstein H G, Schwarzberg H, Poeggel G, Reiser M
Institute for Anatomy, Medical Academy Magdeburg, Germany.
Pharmacol Biochem Behav. 1994 Mar;47(3):587-90. doi: 10.1016/0091-3057(94)90163-5.
We studied the influence of single intracerebroventricular (ICV) and intraperitoneal (IP) injections of the neurotoxin aluminum on the retrieval of a passive avoidance task in rats and on the vasopressin-evoked improvement of the recall of the task. It was found that ICV administration of the metal alone strongly decreases the retention time of a passive avoidance task, whereas IP application of aluminum prolongs it. Vasopressin given ICV and IP leads to an enhancement of retrieval (prolongation of the retention time). Vasopressin in combination with aluminum does not improve the recall of the task when both substances are given ICV. Intraperitoneal injection of the neuropeptide together with the metal improves the recall of the task. Our data point to the crucial importance of the route of application of aluminum for behavioral studies.
我们研究了单次脑室内（ICV）和腹腔内（IP）注射神经毒素铝对大鼠被动回避任务记忆恢复以及血管加压素诱发的该任务记忆改善的影响。结果发现，单独脑室内给予金属铝会强烈缩短被动回避任务的保持时间，而腹腔内注射铝则会延长该时间。脑室内和腹腔内给予血管加压素会导致记忆恢复增强（保持时间延长）。当两种物质都通过脑室内给予时，血管加压素与铝联合使用并不能改善任务记忆。腹腔内注射神经肽与金属铝一起可改善任务记忆。我们的数据表明，铝的给药途径在行为学研究中至关重要。
