Petersson C, Pandis N, Rizou H, Mertens F, Dietrich C U, Adeyinka A, Idvall I, Bondeson L, Georgiou G, Ingvar C, Heim S, Mitelman F
Department of Clinical Genetics, Lund University Hospital, Sweden.
Int J Cancer. 1997 Jan 27;70(3):282-6. doi: 10.1002/(sici)1097-0215(19970127)70:3<282::aid-ijc6>3.0.co;2-t.
Short-term cultures of 50 fibroadenomas of the breast were cytogenetically analyzed. Nine tumors were found to display clonal chromosome aberrations. One had multiple, cytogenetically unrelated clones, whereas the others had a single abnormal clone each. Four cases had one balanced translocation as the sole anomaly, and one had a complex intrachromosomal rearrangement of chromosome 3, leading to loss of 3p material. One fibroadenoma had a single numerical aberration, and one had supernumerary ring chromosomes. The remaining 2 cases had both numerical and structural aberrations. The only recurrent alterations were trisomy 20 and rearrangement of chromosome arm 1p. The finding of similar chromosomal aberrations in fibroadenomas and carcinomas suggests that women with karyotypically abnormal fibroadenomas may have an increased risk of developing subsequent breast cancer. If so, different chromosome anomalies might have different pathogenetic and/or prognostic significance.
对50例乳腺纤维腺瘤进行了短期培养，并进行了细胞遗传学分析。发现9例肿瘤显示出克隆性染色体异常。1例有多个细胞遗传学上不相关的克隆，而其他病例各有一个单一的异常克隆。4例以一个平衡易位作为唯一异常，1例有3号染色体复杂的染色体内重排，导致3p物质缺失。1例纤维腺瘤有一个单一的数目异常，1例有额外的环状染色体。其余2例既有数目异常又有结构异常。唯一反复出现的改变是20号染色体三体和1号染色体臂重排。在纤维腺瘤和癌中发现相似的染色体异常表明，核型异常的纤维腺瘤女性患后续乳腺癌的风险可能增加。如果是这样，不同的染色体异常可能具有不同的致病和/或预后意义。
