乳腺纤维腺瘤中克隆性染色体畸变的意义

Significance of clonal chromosome aberrations in breast fibroadenomas.

作者信息

Rohen C, Staats B, Bonk U, Bartnitzke S, Bullerdiek J

机构信息

Center for Human Genetics and Genetic Counseling, University of Bremen, Germany.

出版信息

Cancer Genet Cytogenet. 1996 Apr;87(2):152-5. doi: 10.1016/0165-4608(95)00239-1.

DOI:10.1016/0165-4608(95)00239-1

PMID:8625262

Abstract

Despite the high frequency of fibroadenomas of the breast, cytogenetic results are relatively limited. We describe our cytogenetic findings in 30 fibroadenomas. Of these, three showed clonal chromosome abnormalities, i.e., 46,XX,der(6)t(1;6)(q25;p21.3); 48,XX,del(6)(q21),r(11)(?),der(14)t(6;14)(q21;q32),+2mar; and 47,XX,+5.

摘要

尽管乳腺纤维腺瘤的发生率很高，但其细胞遗传学结果相对有限。我们描述了30例纤维腺瘤的细胞遗传学发现。其中，3例显示克隆性染色体异常，即46,XX,der(6)t(1;6)(q25;p21.3)；48,XX,del(6)(q21),r(11)(?),der(14)t(6;14)(q21;q32),+2mar；以及47,XX,+5。