Hasegawa M, Fujimoto M, Kikuchi K, Takehara K
Department of Dermatology, Kanazawa University School of Medicine, Japan.
J Rheumatol. 1997 Feb;24(2):328-32.
To determine whether serum interleukin 4 (IL-4), IL-10, and IL-13 levels in patients with systemic sclerosis (SSc) are elevated and whether they correlate with the clinical or serologic features of this disease.
Serum samples from patients with limited cutaneous SSc (ISSc) (n = 45), diffuse cutaneous SSc (dSSc) (n = 28), and control subjects (n = 30) were examined by ELISA.
Serum IL-4 and IL-13 levels were significantly higher in patients with ISSc and dSSc than in the controls. Serum IL-10 levels were significantly higher in the patients with dSSc compared with controls. Elevated IL-10 levels were detected frequently in patients with arthralgia. Serum IL-13 levels correlated with erythrocyte sedimentation rates and C-reactive protein levels in patients.
We suggest that IL-4, IL-10, and IL-13 may be some of the cytokines that contribute to the disease process, and that IL-13 may be a serologic indicator of systemic inflammation in patients with SSc.
确定系统性硬化症（SSc）患者血清白细胞介素4（IL-4）、IL-10和IL-13水平是否升高，以及它们是否与该疾病的临床或血清学特征相关。
采用酶联免疫吸附测定法（ELISA）检测局限性皮肤型SSc（ISSc）患者（n = 45）、弥漫性皮肤型SSc（dSSc）患者（n = 28）及对照者（n = 30）的血清样本。
ISSc和dSSc患者的血清IL-4和IL-13水平显著高于对照组。dSSc患者的血清IL-10水平显著高于对照组。关节痛患者中经常检测到IL-10水平升高。患者的血清IL-13水平与红细胞沉降率和C反应蛋白水平相关。
我们认为IL-4、IL-10和IL-13可能是参与疾病进程的部分细胞因子，并且IL-13可能是SSc患者全身炎症的血清学指标。
