系统性硬化症患者血清肿瘤坏死因子-α水平升高：与肺纤维化的关联
Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis.
作者信息
Hasegawa M, Fujimoto M, Kikuchi K, Takehara K
机构信息
Department of Dermatology, Kanazawa University School of Medicine, Japan.
出版信息
J Rheumatol. 1997 Apr;24(4):663-5.
OBJECTIVE
To determine whether serum tumor necrosis factor-alpha (TNF-alpha) levels are elevated, and whether they correlate with clinical features in patients with systemic sclerosis (SSc).
METHODS
Serum samples from patients with limited cutaneous SSc (ISSc) (n = 51), diffuse cutaneous SSc (dSSc) (n = 30), and control subjects (n = 30) were examined by ELISA.
RESULTS
Serum TNF-alpha levels were elevated in patients with ISSc and dSSc and correlated with the presence of pulmonary fibrosis and with the decreased vital capacity of the patients.
CONCLUSION
Serum TNF-alpha may be one of the cytokines that contribute to the disease process, especially to pulmonary fibrosis in patients with SSc.
目的
确定系统性硬化症（SSc）患者血清肿瘤坏死因子-α（TNF-α）水平是否升高，以及这些水平是否与临床特征相关。
方法
采用酶联免疫吸附测定法（ELISA）检测局限性皮肤型SSc（lSSc）患者（n = 51）、弥漫性皮肤型SSc（dSSc）患者（n = 30）及对照受试者（n = 30）的血清样本。
结果
lSSc和dSSc患者的血清TNF-α水平升高，且与肺纤维化的存在以及患者肺活量降低相关。
结论
血清TNF-α可能是导致疾病进程，尤其是SSc患者肺纤维化的细胞因子之一。
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