Selvaag E
Department of Dermatology, Ullevaal Hospital, University of Oslo, Norway.
Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):293-6. doi: 10.1007/pl00005053.
The NHIK 3025 cell line (Norsk Hydro Institutt for Kreftforskning), a human in situ carcinoma of the cervix cell line, was used to investigate the thiazides bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and xipamide for their potential phototoxic properties. Cell death following UVA irradiation and dependent on test substance concentration was observed in the presence of all the tested substances except chlortalidone, furosemide, indapamide and xipamide. Bendroflumethiazide was phototoxic at concentrations of 0.05 mM and higher; bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 0.25 mM and higher and butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 0.5 mM and higher.
NHIK 3025细胞系（挪威水电公司癌症研究机构），一种人宫颈癌原位细胞系，用于研究噻嗪类药物苄氟噻嗪、苄氢氯噻嗪、布美他尼、布噻嗪、氯噻酮、呋塞米、氢氯噻嗪、氢氟噻嗪、吲达帕胺、吡咯他尼、多噻嗪、三氯噻嗪和希帕胺的潜在光毒性。除氯噻酮、呋塞米、吲达帕胺和希帕胺外，在所有受试物质存在的情况下，均观察到UVA照射后细胞死亡且与受试物质浓度有关。苄氟噻嗪在浓度为0.05 mM及更高时具有光毒性；苄氟噻嗪、苄氢氯噻嗪、布美他尼和氢氟噻嗪在0.25 mM及更高时具有光毒性，布噻嗪、氢氯噻嗪、吡咯他尼、多噻嗪和三氯噻嗪在0.5 mM及更高时具有光毒性。
