Dodson R F, Chu L W, Welch K M, Achar V S
J Neurol Sci. 1977 Aug;33(1-2):161-70. doi: 10.1016/0022-510x(77)90190-3.
The Mongolian gerbil, because of the uniqueness of the anatomical features of its circle of Willis, has become an increasingly useful model in the study of cerebrovascular disease. The present work defines acute changes at the ultrastructural level following ischemic insult. The pathomorphological responses include initial astrocytic involvement and, when the degree of insult is increased, a progression of morphological changes is evident in neuronal and other parenchymal elements. Animals with vessels occluded for more than 3 hr without neurological signs suggestive of ischemia exhibited limited perivascular edema. Contralateral changes (perivascular astrocytic) were observed in the basal ganglia at 24 hr in animals with neurological deficit. Astrocytic and basal ganglia susceptibility to ischemia was consistent with previous findings in primate models. An additional association was found in that limited edematous involvement could exist in animals without neurological deficit but neuronal changes were only present in animals with signs of ischemic neurological deficit.
蒙古沙鼠由于其Willis环解剖结构的独特性，已成为脑血管疾病研究中越来越有用的模型。目前的研究确定了缺血性损伤后超微结构水平的急性变化。病理形态学反应包括最初的星形细胞参与，并且当损伤程度增加时，神经元和其他实质成分的形态变化进展明显。血管闭塞超过3小时而无缺血性神经症状的动物表现出有限的血管周围水肿。在有神经功能缺损的动物中，24小时时在基底神经节观察到对侧变化（血管周围星形细胞变化）。星形细胞和基底神经节对缺血的易感性与灵长类动物模型先前的研究结果一致。还发现了另一种关联，即无神经功能缺损的动物可能存在有限的水肿累及，但神经元变化仅出现在有缺血性神经功能缺损体征的动物中。
