Worsley S D, Ponder B A, Davies B R
Wellbeing Ovarian Cancer Research Centre, Department of Pathology, University of Cambridge, United Kingdom.
Gynecol Oncol. 1997 Feb;64(2):189-95. doi: 10.1006/gyno.1996.4569.
Amplification and overexpression of the cell cycle-related gene cyclin D1 have been demonstrated in several human malignancies and have been shown to be directly oncogenic in breast epithelium and lymphocytes. Overexpression of the gene can occur in the absence of gene amplification. We have investigated whether cyclin D1 is overexpressed in a panel of 43 sporadic epithelial ovarian cancers using immunohistochemistry. Cyclin D1 was overexpressed in 26% of these tumors. Overexpression of cyclin D1 is associated with borderline or well-differentiated, grade 1 tumors but does not correlate with a particular histological type, overexpression of the c-erb-B2 oncogene, or presence of estrogen receptors. It is suggested that overexpression of cyclin D1 may contribute to the pathogenesis of epithelial ovarian cancers, including a subset of tumors different from those overexpressing the c-erb-B2 oncogene.
细胞周期相关基因细胞周期蛋白D1（cyclin D1）的扩增和过表达已在多种人类恶性肿瘤中得到证实，并已表明其在乳腺上皮和淋巴细胞中具有直接致癌作用。该基因的过表达可在无基因扩增的情况下发生。我们运用免疫组织化学方法研究了细胞周期蛋白D1在一组43例散发性上皮性卵巢癌中是否过表达。细胞周期蛋白D1在26%的这些肿瘤中过表达。细胞周期蛋白D1的过表达与交界性或高分化的1级肿瘤相关，但与特定的组织学类型、c-erb-B2癌基因的过表达或雌激素受体的存在无关。提示细胞周期蛋白D1的过表达可能有助于上皮性卵巢癌的发病机制，包括一部分不同于过表达c-erb-B2癌基因的肿瘤。
