Griewing B, Schminke U, Morgenstern C, Walker M L, Kessler C
Department of Neurology, Ernst-Moritz-Arndt University, Greifswald, Germany.
J Neuroimaging. 1997 Jan;7(1):40-5. doi: 10.1111/jon19977140.
Three-dimensional (3D) ultrasound angiography was performed to diagnose carotid artery atherosclerosis. Thirty-five patients (15 women, 20 men) with a history of cerebrovascular disease were examined using conventional color-coded Doppler ultrasound and 3D ultrasound angiography. Carotid stenosis was initially diagnosed using continuous-wave Doppler ultrasound. To determine intraobserver and interobserver reliabilities, 21 patients were evaluated using 3D ultrasound on three occasions. Sixty-five percent of patients were diagnosed with stenosis of more than 50%. Twenty-two percent of plaques had a smooth surface, 72.9% were ulcerated, and 5.1% were indeterminate. Data collection for 3D imaging required 5 minutes per patient, whereas image processing and plaque volume quantification required 30 minutes. Plaque volume ranged from 0.053 to 0.685 ml. The intraobserver and interobserver variabilities were 4.16 and 5.87%, respectively (r = 0.96, p < 0.0001; r = 0.89, p < 0.0001). 3D Color Doppler and 3D ultrasound angiography assessments of plaque volume differed by 8.5%. Plaques were more precisely differentiated using 3D ultrasound, and plaque volume quantification was less affected by echo shadowing after 3D reconstruction. In comparison to other techniques for the quantification of atherosclerotic lesions. 3D ultrasound angiography offers a more precise quantitative method for prospective, clinical studies of atherosclerosis.
采用三维（3D）超声血管造影术诊断颈动脉粥样硬化。对35例有脑血管疾病史的患者（15例女性，20例男性）进行了常规彩色编码多普勒超声和3D超声血管造影检查。最初使用连续波多普勒超声诊断颈动脉狭窄。为了确定观察者内和观察者间的可靠性，对21例患者分三次进行3D超声评估。65%的患者被诊断为狭窄超过50%。22%的斑块表面光滑，72.9%有溃疡形成，5.1%情况不确定。3D成像的数据采集每位患者需要5分钟，而图像处理和斑块体积定量需要30分钟。斑块体积范围为0.053至0.685毫升。观察者内和观察者间的变异率分别为4.16%和5.87%（r = 0.96，p < 0.0001；r = 0.89，p < 0.0001）。3D彩色多普勒和3D超声血管造影对斑块体积的评估相差8.5%。使用3D超声能更精确地区分斑块，并且3D重建后斑块体积定量受回声阴影的影响较小。与其他动脉粥样硬化病变定量技术相比，3D超声血管造影为动脉粥样硬化的前瞻性临床研究提供了一种更精确的定量方法。
