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正常和炎症性唾液腺中肿瘤生长因子β1表达的免疫组织学分析

Immunohistological analysis of tumour growth factor beta 1 expression in normal and inflamed salivary glands.

作者信息

Kizu Y, Sakurai H, Katagiri S, Shinozaki N, Ono M, Tsubota K, Saito J

机构信息

Department of Oral Medicine, Tokyo Dental College, Chiba, Japan.

出版信息

J Clin Pathol. 1996 Sep;49(9):728-32. doi: 10.1136/jcp.49.9.728.

DOI:10.1136/jcp.49.9.728
PMID:9038756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500721/
Abstract

AIM

To determine whether transforming growth factor-beta 1 (TGF-beta 1) has a pathogenetic role in disease of the salivary glands.

METHODS

An indirect immunohistochemical technique was used to analyse TGF-beta 1 expression in six specimens of normal salivary gland and 23 surgical specimens.

RESULTS

TGF-beta 1 was strongly expressed in the ductal epithelial cells of normal salivary gland tissues (six of six cases) and in inflammatory conditions (eight of 11 cases). In contrast, TGF-beta 1 was not detectable in ductal epithelial cells expressing HLA-DR around infiltrating CD4+ CD45RO+ activated T cells, in the salivary gland tissue of patients with Sjögren's syndrome.

CONCLUSION

Because TGF-beta 1 has an essential role in the mucosal immunity of salivary glands, abnormal expression of this cytokine must be regarded as a candidate in the pathogenesis of Sjögren's syndrome.

摘要

目的

确定转化生长因子-β1（TGF-β1）在唾液腺疾病发病机制中是否具有致病作用。

方法

采用间接免疫组织化学技术分析6例正常唾液腺标本和23例手术标本中TGF-β1的表达情况。

结果

TGF-β1在正常唾液腺组织的导管上皮细胞中呈强表达（6例中的6例），在炎症情况下也呈强表达（11例中的8例）。相比之下，在干燥综合征患者唾液腺组织中，围绕浸润性CD4+CD45RO+活化T细胞表达HLA-DR的导管上皮细胞中未检测到TGF-β1。

结论

由于TGF-β1在唾液腺黏膜免疫中起重要作用，该细胞因子的异常表达必定被视为干燥综合征发病机制中的一个候选因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/41ccf18d5c48/jclinpath00246-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/8d6edc6876f4/jclinpath00246-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/ed1b07b12be3/jclinpath00246-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/45cc3938cbbb/jclinpath00246-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/2b478d1f503f/jclinpath00246-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/a65c7c439770/jclinpath00246-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/079c88c25c14/jclinpath00246-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/41ccf18d5c48/jclinpath00246-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/8d6edc6876f4/jclinpath00246-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/ed1b07b12be3/jclinpath00246-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/45cc3938cbbb/jclinpath00246-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/2b478d1f503f/jclinpath00246-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/a65c7c439770/jclinpath00246-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/079c88c25c14/jclinpath00246-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f513/500721/41ccf18d5c48/jclinpath00246-0037-b.jpg

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2
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Arthritis Rheum. 1993 Jun;36(6):827-35. doi: 10.1002/art.1780360614.
3
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4
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