Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", Policlinico, Piazza Giulio Cesare 1, 70124, Bari, Italy.
National Cancer Institute "Giovanni Paolo II", Viale Orazio Flacco, 70124, Bari, Italy.
Histochem Cell Biol. 2018 Aug;150(2):133-147. doi: 10.1007/s00418-018-1680-y. Epub 2018 May 23.
The link between inflammatory microenvironment and cancer emerged in the last years as a decisive factor in the induction of the pathological epithelial-mesenchymal transition (EMT). The EMT induces changes of cell states converting the epithelial cells to mesenchymal cells when this program is fully executed and EMT has emerged as a central driver of tumor malignancy. Cellular pathways activated by chronic inflammation brought about by chronic infections, by immune-mediated diseases, or by dysregulated wound healing at sites of repetitive tissue injury, constitute risk factors or initial cell transformation and for cancer progression. EMT and its intermediate states have recently been identified as crucial inducers of organ fibrosis, inflammation and tumor progression. In this review, we discuss the current state-of-the-art and latest findings regarding the link between EMT, inflammation, fibrosis and cancer, highlighting the most recent data on EMT-dependent tissue fibrosis during chronic inflammatory salivary glands conditions and salivary glands tumors.
近年来，炎症微环境与癌症之间的联系已成为诱导病理性上皮-间充质转化（EMT）的决定性因素。当该程序完全执行时，EMT 会引起细胞状态的变化，将上皮细胞转化为间充质细胞，EMT 已成为肿瘤恶性的核心驱动因素。慢性感染、免疫介导的疾病或重复组织损伤部位失调的伤口愈合引起的慢性炎症激活的细胞途径构成了癌症进展的风险因素或初始细胞转化。EMT 及其中间状态最近被确定为器官纤维化、炎症和肿瘤进展的关键诱导因素。在这篇综述中，我们讨论了 EMT、炎症、纤维化和癌症之间联系的最新研究现状和最新发现，重点介绍了慢性炎症性唾液腺疾病和唾液腺肿瘤期间 EMT 依赖性组织纤维化的最新数据。
