Wang Bin, Li Zhilin, An Wei, Fan Gaiping, Li Dezhi, Qin Lizheng
Department of Head and Neck Oncology, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Department of Oral and Maxillofacial Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
Front Cell Dev Biol. 2024 Jun 25;12:1399934. doi: 10.3389/fcell.2024.1399934. eCollection 2024.
Sialadenitis and sialadenitis-induced sialopathy are typically caused by obstruction of the salivary gland ducts. Atrophy of the salivary glands in experimental animals caused by duct ligation exhibits a histopathology similar to that of salivary gland sialadenitis. Therefore, a variety of duct ligation/de-ligation models have been commonly employed to study salivary gland injury and regeneration. Duct ligation is mainly characterised by apoptosis and activation of different signaling pathways in parenchymal cells, which eventually leads to gland atrophy and progressive dysfunction. By contrast, duct de-ligation can initiate the recovery of gland structure and function by regenerating the secretory tissue. This review summarizes the animal duct ligation/de-ligation models that have been used for the examination of pathological fundamentals in salivary disorders, in order to unravel the pathological changes and underlying mechanisms involved in salivary gland injury and regeneration. These experimental models have contributed to developing effective and curative strategies for gland dysfunction and providing plausible solutions for overcoming salivary disorders.
涎腺炎及涎腺炎诱发的涎腺病通常由唾液腺导管阻塞引起。在实验动物中，由导管结扎导致的唾液腺萎缩呈现出与唾液腺涎腺炎相似的组织病理学特征。因此，多种导管结扎/松解模型已被广泛用于研究唾液腺损伤与再生。导管结扎的主要特征是实质细胞凋亡及不同信号通路的激活，最终导致腺体萎缩和进行性功能障碍。相比之下，导管松解可通过再生分泌组织启动腺体结构和功能的恢复。本综述总结了用于研究唾液腺疾病病理基础的动物导管结扎/松解模型，以阐明唾液腺损伤与再生所涉及的病理变化及潜在机制。这些实验模型有助于制定针对腺体功能障碍的有效治疗策略，并为克服唾液腺疾病提供合理的解决方案。
