101种抗菌药物及其他制剂对微小隐孢子虫体外发育的作用
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
作者信息
Woods K M, Nesterenko M V, Upton S J
机构信息
Division of Biology, Kansas State University, Manhattan 66506, USA.
出版信息
Ann Trop Med Parasitol. 1996 Dec;90(6):603-15. doi: 10.1080/00034983.1996.11813090.
An in-situ ELISA was used as a primary screen to test the effects of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro. Over 40 of the compounds displayed some form of anticryptosporidial activity, and dose-response curves were generated for 40 of these. The in-situ ELISA makes a highly effective primary, pharmaceutical screen for C parvum, to be used prior to more detailed microscopical, toxicological or in-vivo assays.
采用原位酶联免疫吸附测定法作为初步筛选手段，以检测101种抗菌剂和其他药剂对微小隐孢子虫体外发育的影响。超过40种化合物表现出某种形式的抗隐孢子虫活性，并针对其中40种生成了剂量反应曲线。原位酶联免疫吸附测定法是一种对微小隐孢子虫非常有效的初步药物筛选方法，可在进行更详细的显微镜、毒理学或体内试验之前使用。
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