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肠道神经系统形成中的基因与谱系

Genes and lineages in the formation of the enteric nervous system.

作者信息

Gershon M D

机构信息

Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

出版信息

Curr Opin Neurobiol. 1997 Feb;7(1):101-9. doi: 10.1016/s0959-4388(97)80127-4.

DOI:10.1016/s0959-4388(97)80127-4
PMID:9039795
Abstract

The enteric nervous system is large, complex, and independent of the CNS. Its neural-crest-derived precursors migrate along defined pathways to colonize the bowel. Recent studies of the sequential actions of essential growth and transcription factors have revealed that enteric neuronal development involves a complex interaction of lineage-determined and microenvironmental elements.

摘要

肠神经系统庞大、复杂且独立于中枢神经系统。其源自神经嵴的前体细胞沿着特定路径迁移，以在肠道中定植。近期对关键生长因子和转录因子相继作用的研究表明，肠神经元发育涉及谱系决定因素和微环境因素的复杂相互作用。

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