Carpenter R D, Sikich N, Levine M, Lerman J
Department of Anaesthesia, Waikato Hospital, Hamilton, New Zealand.
Paediatr Anaesth. 1997;7(1):25-31. doi: 10.1046/j.1460-9592.1997.d01-36.x.
To determine the quality of anaesthesia and speed of recovery after propofol anaesthesia for myringotomy in children, 100 children 2-12 years were randomized to one of four anaesthetic regimens for induction/maintenance: thiopentone (STP) (5 mg.kg-1)/halothane, propofol (3 mg.kg-1)/halothane, halothane/halothane or propofol (3 mg.kg-1)/propofol bolus (0.5 mg.kg-1 every 3 min (10 mg.kg-1.h-1)). Nitrous oxide (70%) in oxygen (30%) was used to facilitate insertion of an intravenous catheter and was continued throughout the anaesthetic. We found that the incidence of intraoperative movement in response to surgical stimulation was significantly greater in the prop/prop group 32%, compared with the three other groups (P < 0.02). Although some recovery variables (time to response to questions, sit unaided, tolerate oral fluids, and discharge with fluids) were achieved more rapidly by the prop/ prop group than the other three groups, the times to open eyes, obey commands and, most importantly, discharge from recovery without fluids did not differ between the prop/prop and the hal/ hal groups. We conclude that there is little benefit in using propofol as an induction agent alone or in combination with a propofol maintenance anaesthetic for paediatric myringotomy and tube surgery.
为了确定丙泊酚用于儿童鼓膜切开术麻醉后的麻醉质量和恢复速度,将100名2至12岁的儿童随机分为四种诱导/维持麻醉方案之一:硫喷妥钠(STP)(5mg·kg⁻¹)/氟烷、丙泊酚(3mg·kg⁻¹)/氟烷、氟烷/氟烷或丙泊酚(3mg·kg⁻¹)/丙泊酚推注(每3分钟0.5mg·kg⁻¹(10mg·kg⁻¹·h⁻¹))。使用氧化亚氮(70%)和氧气(30%)以利于插入静脉导管,并在整个麻醉过程中持续使用。我们发现,与其他三组相比,丙泊酚/丙泊酚组术中对手术刺激产生运动反应的发生率显著更高,为32%(P<0.02)。虽然丙泊酚/丙泊酚组在一些恢复变量(回答问题的时间、独自坐起、耐受口服液体以及带液体出院)方面比其他三组更快达到,但丙泊酚/丙泊酚组与氟烷/氟烷组在睁眼时间、服从指令时间,以及最重要的不带液体从恢复室出院的时间方面并无差异。我们得出结论,对于小儿鼓膜切开术和置管手术,单独使用丙泊酚作为诱导剂或与丙泊酚维持麻醉联合使用几乎没有益处。