Webber J, Kessel D, Fromm D
Department of Surgery, Wayne State University, Detroit, MI 48201, USA.
J Photochem Photobiol B. 1997 Jan;37(1-2):151-3. doi: 10.1016/s1011-1344(96)07348-4.
We report on the pharmacokinetics of PP formation and elimination in 4 patients after the administration of oral ALA (60 mg kg-1). After a brief distribution phase, plasma PP levels decline (half life = 8 h) and was almost undetectable by 48 h post-administration. This confirms pharmacokinetic clinical data which show that ALA in a shortened interval of skin photosensitization compared with other sensitizers such as Photofrin and 'HPD'. A brief summary of other clinical-toxicity findings is reported.
我们报告了4例口服ALA（60mg/kg）后原卟啉（PP）形成和消除的药代动力学情况。经过短暂的分布期后，血浆PP水平下降（半衰期 = 8小时），给药后48小时几乎检测不到。这证实了药代动力学临床数据，该数据表明与其他光敏剂如卟吩姆钠和“血卟啉衍生物”相比，ALA的皮肤光敏化间隔时间缩短。本文还报告了其他临床毒性研究结果的简要总结。
