Jensen N, Lindblad B, Ljungberg J, Leide S, Bergqvist D
Department of Surgery, Lund University, Malmö University Hospital, Sweden.
Br J Surg. 1997 Jan;84(1):52-7. doi: 10.1046/j.1365-2168.1997.02489.x.
There is a need for prosthetic venous conduits in surgery for trauma, cancer and thrombotic disease. Such conduits in use today have a low patency rate, leaving room for much improvement.
This experimental study investigated the dynamics of the early attachment of radiolabelled platelets, leucocytes and fibrinogen to endothelial cell-seeded Dacron venous conduits in sheep. Grafts were placed as jugular vein interposition grafts, seeded on one side, not seeded on the other, and followed for 4 h.
No difference could be demonstrated between the two graft types. Platelets showed an increasing attachment during the whole period, leucocytes an immediate attachment followed by an undulating pattern, and fibrinogen an immediate attachment with a tendency to decrease. Measurements on the vein itself showed a high attachment and, for platelets, an extremely high attachment when measured after the graft in the direction of flow.
The seeding process did not seem to affect early thrombogenicity. The carefully dissected vein wall showed highly thrombogenic properties, in many ways as high as in the prosthetic graft.
在创伤、癌症和血栓性疾病的手术中，需要人工静脉导管。目前使用的此类导管通畅率较低，仍有很大的改进空间。
本实验研究了放射性标记的血小板、白细胞和纤维蛋白原在绵羊体内内皮细胞种植的涤纶静脉导管上早期黏附的动态过程。将移植物作为颈静脉间置移植物放置，一侧种植内皮细胞，另一侧不种植，观察4小时。
两种移植物类型之间未显示出差异。血小板在整个时间段内黏附增加，白细胞立即黏附，随后呈波动模式，纤维蛋白原立即黏附并呈下降趋势。对静脉本身的测量显示黏附性很高，对于血小板，在顺血流方向测量移植物后，其黏附性极高。
种植过程似乎并未影响早期血栓形成性。仔细解剖的静脉壁显示出高度的血栓形成特性，在许多方面与人工移植物一样高。
