Panjwani U, Singh S B, Verma S S, Yadav D K, Selvamurthy W
Defence Institute of Physiology and Allied Sciences, Timarpur, Delhi, India.
Jpn J Physiol. 1996 Oct;46(5):397-402. doi: 10.2170/jjphysiol.46.397.
The study was carried out to evaluate the effect of different degrees of hypothermia on nerve conduction and the possible beneficial effect of vitamin C in the amelioration of the impairment in nerve conduction due to hypothermia. Sixty male Wistar rats, 225-250 g, were randomly divided into two equal groups of untreated controls and vitamin C treated experimental groups. Sciatic nerve conduction and nerve temperature (Tn) were recorded at different degrees of hypothermia by step-wise lowering of rectal temperature (Tr) from 38 to 20 degrees C. A regression analysis showed a positive linear relationship of Tr with nerve conduction velocity (NCV) and with Tn in both groups (p < 0.001). There was also a positive linear relationship between Tn and NCV in both groups: control, p < 0.001; experimental, p < 0.05. Comparisons between the regression equations of Tr with NCV, Tr with Tn, and Tn with NCV showed significant differences between the two groups (p < 0.001). There was no significant relationship between Tr and the amplitude of the action potential. Vitamin C may have a protective effect against the impairment of NCV due to hypothermia.
本研究旨在评估不同程度低温对神经传导的影响，以及维生素C在改善低温所致神经传导损伤方面可能的有益作用。选取60只体重225 - 250克的雄性Wistar大鼠，随机分为未处理的对照组和维生素C处理的实验组，每组各30只。通过逐步将直肠温度（Tr）从38℃降至20℃，记录不同程度低温下的坐骨神经传导和神经温度（Tn）。回归分析表明，两组中Tr与神经传导速度（NCV）以及Tr与Tn均呈正线性关系（p < 0.001）。两组中Tn与NCV之间也呈正线性关系：对照组，p < 0.001；实验组，p < 0.05。Tr与NCV、Tr与Tn以及Tn与NCV的回归方程比较显示，两组之间存在显著差异（p < 0.001）。Tr与动作电位幅度之间无显著关系。维生素C可能对低温所致的NCV损伤具有保护作用。
