Panjwani Usha, Yadav Deepak K, Kumar Amitabh, Singh S B, Selvamurthy W
Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, India.
Int J Biometeorol. 2003 Dec;48(2):103-7. doi: 10.1007/s00484-003-0183-1. Epub 2003 Jun 24.
Exposure to an extremely cold environment without proper protection leading to hypothermia is an emergency, one of the several complications of which is impairment in nerve conduction. Our previous work in the rat model has shown the beneficial effect of vitamin C in modulating the effect of hypothermia on nerve conduction. The present study aimed to evaluate the effect of vitamins C and E, administered alone or in combination, in modulating the effect of mild hypothermia on human ulnar nerve conduction. The study was carried out on 26 volunteers divided into three groups: group I received vitamin C supplementation (2000 mg/day in a single dose and 1,000 mg/day for the next 6 days), group II received vitamins C and E in combination (1,000 mg and 800 mg respectively in a single dose and 500 mg and 400 mg respectively for the next 6 days) and group III received vitamin E (800 mg in a single dose and the same for the next 6 days). The recordings were carried out before and after single and weekly supplementation in each group. There was a fall in ulnar nerve conduction velocity with a reduction in the oral temperature of 2-2.5 degrees C. Vitamin C administered alone and in combination with vitamin E reduced the fall in ulnar nerve conduction velocity. Prior supplementation with vitamin C and E could help ameliorate the impairment in human ulnar nerve conduction due to hypothermia.
在没有适当防护的情况下暴露于极冷环境导致体温过低是一种紧急情况，其并发症之一是神经传导受损。我们之前在大鼠模型中的研究表明，维生素C在调节体温过低对神经传导的影响方面具有有益作用。本研究旨在评估单独或联合使用维生素C和E对轻度体温过低对人尺神经传导的影响。该研究对26名志愿者进行，分为三组：第一组接受维生素C补充（单次剂量2000毫克/天，接下来6天每天1000毫克），第二组联合接受维生素C和E（单次剂量分别为1000毫克和800毫克，接下来6天分别为500毫克和400毫克），第三组接受维生素E（单次剂量800毫克，接下来6天相同）。在每组单次和每周补充前后进行记录。随着口腔温度降低2 - 2.5摄氏度，尺神经传导速度下降。单独使用维生素C以及与维生素E联合使用可减少尺神经传导速度的下降。预先补充维生素C和E有助于改善因体温过低导致的人尺神经传导受损。
