Tsai T H, Chang T C, Chiang C P
Department of Internal Medicine and School of Dentistry, National Taiwan University Hospital, Taipei, Republic of China.
Anal Quant Cytol Histol. 1997 Feb;19(1):45-8.
To determine whether nuclear area (NA) measurement could help to differentiate parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma in aspirated smears.
Aspirated smears of 15 patients with parathyroid adenoma, 11 patients with parathyroid hyperplasia and 11 patients with thyroid follicular adenoma were included. NA of 100 cells in each case were measured by image analysis; then the mean and coefficient of variation were calculated.
There was no statistically significant difference in the mean of NA between parathyroid adenoma and parathyroid hyperplasia, but the former displayed greater NA variation. Thyroid follicular adenoma revealed a significant elevation in the mean of NA when compared with parathyroid lesions and also shared the feature of greater NA variation when compared with parathyroid hyperplasia, as noted in parathyroid adenoma.
Quantitative assessments on NA and calculation of their coefficient of variation are helpful in differentiating between parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma.
确定细胞核面积（NA）测量是否有助于鉴别细针穿刺涂片检查中的甲状旁腺腺瘤、甲状旁腺增生及甲状腺滤泡性腺瘤。
纳入15例甲状旁腺腺瘤患者、11例甲状旁腺增生患者及11例甲状腺滤泡性腺瘤患者的细针穿刺涂片。采用图像分析测量每种病例中100个细胞的细胞核面积；然后计算平均值及变异系数。
甲状旁腺腺瘤与甲状旁腺增生的细胞核面积平均值无统计学显著差异，但前者的细胞核面积变异更大。与甲状旁腺病变相比，甲状腺滤泡性腺瘤的细胞核面积平均值显著升高，且与甲状旁腺增生相比，其细胞核面积变异更大，这一特点与甲状旁腺腺瘤相同。
对细胞核面积进行定量评估并计算其变异系数有助于鉴别甲状旁腺腺瘤、甲状旁腺增生及甲状腺滤泡性腺瘤。
