Baker L L, Chambers R, DeMuth S K, Villar F
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles 90033, USA.
Diabetes Care. 1997 Mar;20(3):405-12. doi: 10.2337/diacare.20.3.405.
To evaluate the effects of two stimulation waveforms on healing rates in patients with diabetes and open ulcers. The hypothesis was that stimulus waveforms with minimal polar characteristics would provide significant healing for this patient sample.
This was a prospective study that enrolled 80 patients with open ulcers. Patients received stimulation with either an asymmetric biphasic (A) or symmetric biphasic (B) square-wave pulse. Amplitudes were set to activate intact peripheral nerves in the skin. Two other groups received either very low levels of stimulation current (MC), or no electrical stimulation (C). When combined these groups were referred to as the control group. Treatment was carried out daily until the wound healed, the patient withdrew from the study, or the physician changed the overall wound management program. Average healing rates were calculated from weekly measures of the wound perimeter and were used for statistical comparison through a one-way analysis of variance.
Stimulation with the A protocol significantly increased the healing rate, enhancing healing by nearly 60% over the control rate of healing. Stimulation with the B protocol did not increase the healing rate when compared with control subjects.
Electrical stimulation, given daily with a short pulsed, asymmetric biphasic waveform, was effective for enhancement of healing rates for patients with diabetes and open ulcers.
评估两种刺激波形对糖尿病开放性溃疡患者愈合率的影响。假设是具有最小极性特征的刺激波形将为该患者样本提供显著的愈合效果。
这是一项前瞻性研究，纳入了80例开放性溃疡患者。患者接受不对称双相（A）或对称双相（B）方波脉冲刺激。将振幅设置为激活皮肤中完整的周围神经。另外两组分别接受极低水平的刺激电流（MC）或无电刺激（C）。这些组合并后称为对照组。每天进行治疗，直到伤口愈合、患者退出研究或医生更改整体伤口管理方案。根据每周测量的伤口周长计算平均愈合率，并通过单因素方差分析进行统计比较。
采用A方案刺激显著提高了愈合率，与对照愈合率相比，愈合率提高了近60%。与对照受试者相比，采用B方案刺激并未提高愈合率。
每天给予短脉冲、不对称双相波形的电刺激对提高糖尿病开放性溃疡患者的愈合率有效。
