Halme L, Edgren J, Turpeinen U, von Smitten K, Stenman U H
Fourth Dept. of Surgery, Helsinki University Hospital, Finland.
Scand J Gastroenterol. 1997 Feb;32(2):148-52. doi: 10.3109/00365529709000185.
Increased intestinal permeability of water-soluble contrast medium during an intestinal follow-through is found in patients with active Crohn's disease in the small bowel.
Urinary excretion of the water-soluble X-ray contrast medium iohexol was measured after oral administration in patients with inflammatory bowel disease and in healthy controls. The patients were grouped on the basis of disease activity and location and extent of intestinal involvement.
Urinary excretion of iohexol was significantly higher in patients with active disease than in patients with quiescent disease or in healthy controls (P = 0.005), and it correlated positively with activity indices and with the extent of the disease.
The intestinal permeability of iohexol is significantly increased in patients with active inflammatory bowel disease in the small bowel and in the colon, whereas the permeability of patients with inactive disease is similar to that in healthy controls. We suggest that urinary excretion of iohexol can be used as a marker of disease activity in patients with inflammatory bowel disease.
在小肠型活动性克罗恩病患者的肠道通过造影检查中，发现水溶性造影剂的肠道通透性增加。
对炎性肠病患者和健康对照者口服水溶性X线造影剂碘海醇后，测量其尿排泄量。根据疾病活动度、肠道受累部位及范围对患者进行分组。
活动性疾病患者碘海醇的尿排泄量显著高于静止期疾病患者或健康对照者（P = 0.005），且与活动指数及疾病范围呈正相关。
小肠和结肠型活动性炎性肠病患者碘海醇的肠道通透性显著增加，而静止期疾病患者的通透性与健康对照者相似。我们建议碘海醇的尿排泄量可作为炎性肠病患者疾病活动度的标志物。
