Khamidov D Kh, Abliaeva N Kh, Shulakova T Iu, Dul'man R A
Probl Endokrinol (Mosk). 1977 Mar-Apr;23(2):91-4.
The influence of various amounts (0.008; 0.0025; 0.25 microgram per 1 g of body weight of the embryo) of thyroxin on the energy processes of the embryonic tissue was studied. On the 10th, 13th, and 16th days of the embryonic development low and medium doses of thyroxin failed to alter the rate of respiration and of phosphorylation in the liver homogenates. An increase of the oxygen consumption intensity without the change of the respiratory control (RC), P/O in the succinate oxidation occurred in the heart tissue. On the 19th day thyroxin uncoupled the oxidative phosphorylation in the glutamate oxidation. High hormone doses decreased the rate of respiration, RC in the liver at all the embryogenesis stages, and failed to influence the heart.
研究了不同剂量（每1克胚胎体重0.008；0.0025；0.25微克）甲状腺素对胚胎组织能量代谢过程的影响。在胚胎发育的第10、13和16天，低剂量和中等剂量的甲状腺素未能改变肝脏匀浆中的呼吸速率和磷酸化速率。心脏组织中琥珀酸氧化时，氧气消耗强度增加，而呼吸控制（RC）、P/O不变。在第19天，甲状腺素使谷氨酸氧化中的氧化磷酸化解偶联。高剂量激素在胚胎发育的所有阶段均降低了肝脏中的呼吸速率和RC，对心脏无影响。
