Murzina G B, Sil'kis I G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Nov-Dec;46(6):1076-87.
The participation of inhibition in the long-term contrasting of neural interconnections was studied using the mathematical model of posttetanic calcium-dependent postsynaptic processes in a CA3 hippocampal pyramidal cell. It was demonstrated that if a presynaptic neuron fired during some time with a given frequency the modifiable inhibition selectively promoted the long-term potentiation of the efficacy of excitatory connection between the pre- and postsynaptic cells, while the efficacy of other inputs to the same postsynaptic cell were depressed. The long-term depression of the efficacy of disynaptic inhibitory input underlies such contrasting even in the case when the efficacy of the excitatory input is low and weakly potentiated. Concerning other inputs, we suppose that if the "common" inhibitory interneuron is simultaneously activated by different presynaptic cells, the long-term heterosynaptic potentiation of the inhibitory transmission will be induced. This effect together with the unmodifiable excitatory heterosynaptic transmission will lead to the long-term depression of the excitatory connections between various presynaptic cells and the given postsynaptic cell.
利用海马体CA3区锥体细胞中强直后钙依赖性突触后过程的数学模型，研究了抑制作用在神经互连长期对比中的参与情况。结果表明，如果突触前神经元在一段时间内以给定频率放电，可修饰的抑制作用会选择性地促进突触前和突触后细胞之间兴奋性连接效率的长期增强，而同一突触后细胞的其他输入效率则会降低。即使在兴奋性输入效率较低且增强较弱的情况下，双突触抑制性输入效率的长期抑制也是这种对比的基础。关于其他输入，我们假设，如果“共同”的抑制性中间神经元同时被不同的突触前细胞激活，将诱导抑制性传递的长期异突触增强。这种效应与不可修饰的兴奋性异突触传递一起，将导致各种突触前细胞与给定突触后细胞之间兴奋性连接的长期抑制。
