Murzina G B, Sil'kis I G
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Neurosci Behav Physiol. 1998 Mar-Apr;28(2):174-82. doi: 10.1007/BF02461964.
Conditions facilitating long-term contrasting of interneuronal connections were studied using a mathematical model of posttetanic Ca(2+)-dependent postsynaptic processes in pyramidal neurons of hippocampal field CA3. These studies demonstrated that modified inhibition selectively facilitates. long-term potentiation of the efficiency of one of the interneuronal connections when the presynaptic neuron discharges at a given frequency for a short time, while connections formed from the same postsynaptic cell with other presynaptic neurons undergo long-term depression. The mechanism underlying this contrasting may involve long-term depression of the efficiency of disynaptic inhibitory transmission to the rhythmically stimulated input, even when the efficiency of monosynaptic excitatory transmission at the same input is low and undergoes minimal potentiation. When the "common" inhibitory neuron is simultaneously activated by various presynaptic cells. heterosynaptic potentiation of inhibitory transmission can simultaneously develop at the other inputs of the postsynaptic cell, without change in the efficiency of excitatory transmission, which leads to long-term depression of the efficiency of the connections between other excitatory neurons and the postsynaptic cell.
利用海马体CA3区锥体细胞强直后钙依赖性突触后过程的数学模型，研究了促进神经元间连接长期对比的条件。这些研究表明，当突触前神经元在给定频率下短时间放电时，修饰抑制选择性地促进了神经元间连接之一效率的长期增强，而由同一突触后细胞与其他突触前神经元形成的连接则经历长期抑制。这种对比的潜在机制可能涉及到对有节奏刺激输入的双突触抑制传递效率的长期抑制，即使同一输入处的单突触兴奋传递效率很低且增强最小。当“共同”抑制性神经元同时被各种突触前细胞激活时，抑制性传递的异突触增强可在突触后细胞的其他输入处同时发生，而兴奋性传递效率不变，这导致其他兴奋性神经元与突触后细胞之间连接效率的长期抑制。
