Mann A H
Psychol Med. 1977 Aug;7(3):431-8. doi: 10.1017/s0033291700004402.
Two hundred and thirty-five entrants into the MRC trial for mild to moderate hypertension were matched with control subjects in order to assess the psychological effects of a screening programme and recruitment into a clinical trial. The prevalence and incidence of psychiatric morbidity among the trial participants were compared with those of the controls by means of responses to a self-administered questionnaire and diagnostic psychiatric interviews. No differences among the groups were shown between screening and entry into the trial, but after entry the prevalence of psychiatric morbidity among the trial participants fell. This was due to a greater improvement of those with psychiatric symptoms at entry in this group, the incidence of new morbidity being similar among the groups.
235名参加医学研究委员会轻度至中度高血压试验的受试者与对照对象进行了匹配，以评估筛查计划及参与临床试验的心理影响。通过对一份自填式问卷的回答以及精神科诊断访谈，将试验参与者中精神疾病的患病率和发病率与对照组进行了比较。在筛查和进入试验阶段，两组之间未显示出差异，但进入试验后，试验参与者中精神疾病的患病率有所下降。这是因为该组中入组时患有精神症状的人改善更大，各组中新发病例的发生率相似。
