31P核磁共振波谱在寡核苷酸研发中的应用
31P NMR spectroscopy in oligonucleotide research and development.
作者信息
Hirschbein B L, Fearon K L
机构信息
Lynx Therapeutics, Hayward, California 94545, USA.
出版信息
Antisense Nucleic Acid Drug Dev. 1997 Feb;7(1):55-61. doi: 10.1089/oli.1.1997.7.55.
PMID:9055040
Abstract
31P NMR is an extremely valuable tool for oligonucleotide research and development. This brief commentary, which is directed to scientists who do not regularly use 31P NMR in their work, attempts to outline some of the principles, considerations, and representative applications of 31P NMR spectroscopy in oligonucleotide research and development.
摘要
31P核磁共振是寡核苷酸研发中极具价值的工具。这篇简短的评论针对那些在工作中不经常使用31P核磁共振的科学家，试图概述31P核磁共振光谱在寡核苷酸研发中的一些原理、注意事项和典型应用。
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