Sersa I, Beravs K, Dodd N J, Zhao S, Miklavcic D, Demsar F
Jozef Stefan Institute, University of Ljubijana, Slovenia.
Magn Reson Med. 1997 Mar;37(3):404-9. doi: 10.1002/mrm.1910370318.
The use of electric current density imaging (CDI) to map spatial distribution of electric currents through tumors is presented. Specifically, a method previously tested on phantoms was implemented in vivo and in vitro for mapping electric current pulses of the same order of magnitude (j approximately 2500 A/m2) as in electrochemotherapy through T50/80 mammary carcinomas, B-16 melanomas and SA-1 sarcomas. A technically simplified method of electric current density imaging is discussed as well. Three geometries of electrodes (flat-flat, point-point, point-flat) indicate altered electric current distribution for the same tumor. This indicates that the method can be used for monitoring the effects of electrochemotherapy as a function of electrode geometry.
介绍了利用电流密度成像（CDI）来绘制电流通过肿瘤的空间分布情况。具体而言，一种先前在模型上测试过的方法在体内和体外实施，用于绘制与通过T50/80乳腺癌、B - 16黑色素瘤和SA - 1肉瘤进行电化学疗法时相同数量级（j约为2500 A/m²）的电流脉冲。还讨论了一种技术上简化的电流密度成像方法。三种电极几何形状（平面 - 平面、点 - 点、点 - 平面）表明，对于同一肿瘤，电流分布有所改变。这表明该方法可用于监测作为电极几何形状函数的电化学疗法效果。
