伏立康唑（UK-109,496）对曲霉属临床分离株的活性及其在侵袭性肺曲霉病实验模型中的有效性。
Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive pulmonary aspergillosis.
作者信息
Murphy M, Bernard E M, Ishimaru T, Armstrong D
机构信息
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
出版信息
Antimicrob Agents Chemother. 1997 Mar;41(3):696-8. doi: 10.1128/AAC.41.3.696.
Abstract
Voriconazole, a new azole antifungal agent, showed potent activity against clinical isolates of Aspergillus spp. in vitro. For A. fumigatus, the MIC range was < 0.03 to 0.5 microgram/ml and the MIC at which 90% of isolates are inhibited was 0.25 microgram/ml. In an experimental model of invasive pulmonary aspergillosis which mimics infection in humans, oral voriconazole at dosages of 30 mg/kg of body weight per day significantly delayed or prevented mortality.
摘要
伏立康唑是一种新型唑类抗真菌药物，在体外对曲霉属临床分离株显示出强大的活性。对于烟曲霉，其最低抑菌浓度（MIC）范围为<0.03至0.5微克/毫升，90%分离株被抑制时的MIC为0.25微克/毫升。在一个模拟人类感染的侵袭性肺曲霉病实验模型中，每天口服30毫克/千克体重的伏立康唑可显著延迟或预防死亡。
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