Kyzer S, Kadouri A, Levi A, Ramadan E, Levinsky H, Halpern M, Chaimoff C
Department of Surgery A, Weizman Institute of Science, Rehovot, Israel.
Eur Surg Res. 1997;29(2):84-92. doi: 10.1159/000129511.
In the present study polyglycolic acid (PGA) mesh was used for repair of fascial defects experimentally made in rats. In the experimental group fibroblasts were cultured on the mesh before implantation and in the control group the mesh alone was used. Rats were sacrificed 7, 14, 28 and 60 days after the implantation of the mesh. Tissues were examined microscopically and for hydroxyproline content. Microscopically good incorporation of the mesh was noted in both the control and experimental groups. However, it seems that in the experimental group earlier dissolution of the mesh occurred. The hydroxyproline content was higher in the experimental group after 7 (statistically not significant) and 14 days (p < 0.05) and in the control group after 28 (p < 0.025) and 60 days (p < 0.05). These results suggest that the use of PGA mesh with cultured fibroblasts might have a beneficial effect on wound healing.
在本研究中，聚乙醇酸（PGA）网片被用于修复大鼠实验性制造的筋膜缺损。在实验组，成纤维细胞在植入前在网片上进行培养，而在对照组仅使用网片。在网片植入后7天、14天、28天和60天处死大鼠。对组织进行显微镜检查并测定羟脯氨酸含量。显微镜下观察到，对照组和实验组中网片的整合情况均良好。然而，似乎实验组中网片的溶解发生得更早。实验组在7天（统计学上无显著差异）和14天后（p<0.05）以及对照组在28天（p<0.025）和60天后（p<0.05）羟脯氨酸含量更高。这些结果表明，使用培养有成纤维细胞的PGA网片可能对伤口愈合有有益作用。
