Kawanami C, Fukui H, Kinoshita Y, Nakata H, Asahara M, Matsushima Y, Kishi K, Chiba T
Department of Internal Medicine, Kyoto University Graduate School of Medicine, Japan.
J Gastroenterol. 1997 Feb;32(1):12-8. doi: 10.1007/BF01213290.
Regenerating (reg) gene expression was tested in rat gastrointestinal mucosa to investigate the role played by this gene in the healing of mucosal lesions. Expression of reg mRNA was higher in the stomach than in any other region of the gastrointestinal tract. The gastric cells that expressed reg mRNA were located in the deepest mucosal layer and were small in diameter. In an injured state following indomethacin treatment, reg gene expression was markedly augmented, accompanied by an increase of c-fos expression and healing of the mucosal lesions. These results suggest a role of the reg gene in the healing of gastrointestinal mucosal lesions.
为研究再生（reg）基因在大鼠胃肠道黏膜损伤愈合中所起的作用，检测了该基因在大鼠胃肠道黏膜中的表达情况。reg mRNA在胃中的表达高于胃肠道的其他任何部位。表达reg mRNA的胃细胞位于黏膜最深层，直径较小。在吲哚美辛处理后的损伤状态下，reg基因表达显著增强，同时c-fos表达增加，黏膜损伤愈合。这些结果提示reg基因在胃肠道黏膜损伤愈合中发挥作用。
