Blanco C, Quiralte J, Castillo R, Delgado J, Arteaga C, Barber D, Carrillo T
Hospital Universitario Nuestra Señora del Pino, Facultad de Ciencias Médicas y de la Salud, Las Palmas de Gran Canaria, Canary Islands, Spain.
J Allergy Clin Immunol. 1997 Mar;99(3):308-13. doi: 10.1016/s0091-6749(97)70047-2.
Anaphylaxis after ingestion of flours contaminated with mites has been recently reported.
The study was designed to determine whether four-induced reactions in the absence of food sensitivity may result from mite contamination.
Patients with systemic reactions after ingestion of foods containing wheat flour and without food sensitivities were included in a prospective study. The flours were examined microscopically, and major Dermatophagoides allergens were quantified by monoclonal antibody techniques. Skin prick tests and IgE determinations to mites and flours were performed. Single-blind, placebo-controlled oral challenges were also performed.
Sixteen patients were included in our protocol. They showed respiratory allergies to dust mites (100%) and intolerance to acetylsalicylic acid (87%). Microscopic examination of four flours implicated in allergic reactions revealed a high degree of mite contamination: Dermatophagoides farinae in one case and Thyreophagus entomophagus in three cases. Our patients' skin test and specific IgE responses to the flours implicated in the reactions were positive. A high level of Der 2 was found in the flour infested by D. farinae. Three of six food challenges with contaminated flours resulted in systemic reactions. Good tolerance to control flours was shown in our patients.
Ingestion of foods contaminated with mites may induce systemic anaphylactic reactions in patients with respiratory allergy to mites.
最近有报道称，摄入被螨虫污染的面粉后会发生过敏反应。
本研究旨在确定在无食物过敏的情况下，面粉诱发的反应是否可能由螨虫污染引起。
摄入含小麦面粉食物后出现全身反应且无食物过敏的患者被纳入一项前瞻性研究。对面粉进行显微镜检查，并通过单克隆抗体技术对主要粉尘螨过敏原进行定量。进行皮肤点刺试验以及针对螨虫和面粉的IgE测定。还进行了单盲、安慰剂对照的口服激发试验。
16名患者纳入我们的研究方案。他们对尘螨表现出呼吸道过敏（100%），对乙酰水杨酸不耐受（87%）。对涉及过敏反应的四种面粉进行显微镜检查发现螨虫污染程度很高：一例为粉螨，三例为嗜虫书虱。我们的患者对涉及反应的面粉的皮肤试验和特异性IgE反应呈阳性。在被粉螨侵染的面粉中发现高水平的Der 2。用受污染面粉进行的六项食物激发试验中有三项导致全身反应。我们的患者对对照面粉耐受性良好。
摄入被螨虫污染的食物可能会在对螨虫有呼吸道过敏的患者中诱发全身过敏反应。
