在人类中鉴定出一种新型外源性逆转录病毒序列。
A novel exogenous retrovirus sequence identified in humans.
作者信息
Griffiths D J, Venables P J, Weiss R A, Boyd M T
机构信息
Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom.
出版信息
J Virol. 1997 Apr;71(4):2866-72. doi: 10.1128/JVI.71.4.2866-2872.1997.
Abstract
A 932-bp retrovirus sequence was cloned by reverse transcriptase PCR from salivary gland tissue of a patient with Sjögren's syndrome. The sequence is related to that of type B and type D retroviruses and was present in a sucrose density gradient fraction corresponding to that of an enveloped retrovirus particle. Sequences amplified from tissues of eight individuals with or without Sjögren's syndrome had over 90% similarity and were present at a level of less than one copy per 10(3) cells. The sequence was not detectable in human genomic DNA by PCR or by Southern hybridization. These data indicate that the sequence represents an infectiously acquired genome, provisionally called human retrovirus 5.
摘要
通过逆转录酶聚合酶链反应（RT-PCR）从一名干燥综合征患者的唾液腺组织中克隆出一段932碱基对的逆转录病毒序列。该序列与B型和D型逆转录病毒序列相关，且存在于与包膜逆转录病毒颗粒相对应的蔗糖密度梯度级分中。从8名有或没有干燥综合征的个体组织中扩增出的序列具有超过90%的相似性，并且以每10³个细胞中少于一个拷贝的水平存在。通过聚合酶链反应（PCR）或Southern杂交在人类基因组DNA中均未检测到该序列。这些数据表明该序列代表一种通过感染获得的基因组，暂称为人类逆转录病毒5。
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