Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis.
作者信息
Adler B, Adler H, Pfister H, Jungi T W, Peterhans E
机构信息
Institute of Veterinary Virology, University of Bern, Switzerland.
出版信息
J Virol. 1997 Apr;71(4):3255-8. doi: 10.1128/JVI.71.4.3255-3258.1997.
Abstract
Bovine bone marrow-derived macrophages infected with the cytopathic biotype of bovine viral diarrhea virus released an antiviral activity into the supernatant which was tentatively characterized as type I interferon because of its physicochemical properties. Such supernatants primed both infected and uninfected macrophages for decreased nitric oxide production and apoptosis in response to lipopolysaccharide. This finding strongly suggests a role of this pathway in the pathogenesis of mucosal disease, a lethal form of infection with cytopathic bovine viral diarrhea virus in which the principal lesions are located in the oral cavity and the gastrointestinal tract, which are known to contain a high concentration of endotoxin.
摘要
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