感染致细胞病变型牛病毒性腹泻病毒的巨噬细胞释放一种（或多种）因子，该因子能够使未感染的巨噬细胞致敏，从而引发激活诱导的细胞凋亡。
Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis.
作者信息
Adler B, Adler H, Pfister H, Jungi T W, Peterhans E
机构信息
Institute of Veterinary Virology, University of Bern, Switzerland.
出版信息
J Virol. 1997 Apr;71(4):3255-8. doi: 10.1128/JVI.71.4.3255-3258.1997.
Abstract
Bovine bone marrow-derived macrophages infected with the cytopathic biotype of bovine viral diarrhea virus released an antiviral activity into the supernatant which was tentatively characterized as type I interferon because of its physicochemical properties. Such supernatants primed both infected and uninfected macrophages for decreased nitric oxide production and apoptosis in response to lipopolysaccharide. This finding strongly suggests a role of this pathway in the pathogenesis of mucosal disease, a lethal form of infection with cytopathic bovine viral diarrhea virus in which the principal lesions are located in the oral cavity and the gastrointestinal tract, which are known to contain a high concentration of endotoxin.
摘要
感染牛病毒性腹泻病毒细胞病变生物型的牛骨髓来源巨噬细胞将一种抗病毒活性释放到上清液中，由于其物理化学性质，该活性初步被鉴定为I型干扰素。这种上清液使感染和未感染的巨噬细胞对脂多糖刺激产生的一氧化氮生成减少和凋亡受到抑制。这一发现有力地表明该途径在黏膜病发病机制中发挥作用，黏膜病是一种由细胞病变性牛病毒性腹泻病毒引起的致死性感染形式，其主要病变位于口腔和胃肠道，而这些部位已知含有高浓度的内毒素。
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本文引用的文献
1
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
2
Distribution of antigen of noncytopathogenic and cytopathogenic bovine virus diarrhea virus biotypes in the intestinal tract of calves following experimental production of mucosal disease.
Arch Virol Suppl. 1991;3:109-24. doi: 10.1007/978-3-7091-9153-8_13.
3
The pathways for bovine virus diarrhoea virus biotypes in the pathogenesis of disease.牛病毒性腹泻病毒生物型在疾病发病机制中的途径。
Arch Virol Suppl. 1991;3:79-96. doi: 10.1007/978-3-7091-9153-8_10.
4
Cytopathogenicity of pestiviruses isolated post mortem from cattle.死后从牛体分离出的瘟病毒的细胞致病性。
Arch Virol Suppl. 1991;3:67-70. doi: 10.1007/978-3-7091-9153-8_8.
5
Inactivated bovine herpesvirus 1 induces apoptotic cell death of mitogen-stimulated bovine peripheral blood mononuclear cells.灭活的牛疱疹病毒1诱导丝裂原刺激的牛外周血单个核细胞发生凋亡性细胞死亡。
J Virol. 1996 Jun;70(6):4116-20. doi: 10.1128/JVI.70.6.4116-4120.1996.
6
Distribution of cytopathogenic and noncytopathogenic bovine virus diarrhea virus in tissues from a calf with experimentally induced mucosal disease using antigenic and genetic markers.
Arch Virol Suppl. 1993;7:295-302. doi: 10.1007/978-3-7091-9300-6_22.
7
Detection of bovine viral diarrhoea virus p80 protein in subpopulations of bovine leukocytes.牛白细胞亚群中牛病毒性腹泻病毒p80蛋白的检测
J Gen Virol. 1994 May;75 ( Pt 5):1189-94. doi: 10.1099/0022-1317-75-5-1189.
8
Generation and functional characterization of bovine bone marrow-derived macrophages.牛骨髓来源巨噬细胞的生成及功能特性研究
Vet Immunol Immunopathol. 1994 Jun;41(3-4):211-27. doi: 10.1016/0165-2427(94)90098-1.
9
Viral infection of macrophages profoundly alters requirements for induction of nitric oxide synthesis.巨噬细胞的病毒感染会深刻改变诱导一氧化氮合成的条件。
Virology. 1995 Sep 10;212(1):174-8. doi: 10.1006/viro.1995.1465.
10
Altered immune responses in mice lacking inducible nitric oxide synthase.缺乏诱导型一氧化氮合酶的小鼠的免疫反应改变。
Nature. 1995 Jun 1;375(6530):408-11. doi: 10.1038/375408a0.
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