Stewart B F, Siscovick D, Lind B K, Gardin J M, Gottdiener J S, Smith V E, Kitzman D W, Otto C M
Department of Medicine, University of Washington, Seattle 98195-6422, USA.
J Am Coll Cardiol. 1997 Mar 1;29(3):630-4. doi: 10.1016/s0735-1097(96)00563-3.
The aim of this study was to determine the prevalence of aortic sclerosis and stenosis in the elderly and to identify clinical factors associated with degenerative aortic valve disease.
Several lines of evidence suggest that degenerative aortic valve disease is not an inevitable consequence of aging and may be associated with specific clinical factors.
In 5,201 subjects > or = 65 years of age enrolled in the Cardiovascular Health Study, the relation between aortic sclerosis or stenosis identified on echocardiography and clinical risk factors for atherosclerosis was evaluated by using stepwise logistic regression analysis.
Aortic valve sclerosis was present in 26% and aortic valve stenosis in 2% of the entire study cohort; in subjects > or = 75 years of age, sclerosis was present in 37% and stenosis in 2.6%. Independent clinical factors associated with degenerative aortic valve disease included age (twofold increased risk for each 10-year increase in age), male gender (twofold excess risk), present smoking (35% increase in risk) and a history of hypertension (20% increase in risk). Other significant factors included height and high lipoprotein(a) and low density lipoprotein cholesterol levels.
Clinical factors associated with aortic sclerosis and stenosis can be identified and are similar to risk factors for atherosclerosis.
本研究旨在确定老年人主动脉硬化和狭窄的患病率，并确定与退行性主动脉瓣疾病相关的临床因素。
多项证据表明，退行性主动脉瓣疾病并非衰老的必然结果，可能与特定临床因素有关。
在心血管健康研究中纳入的5201名年龄≥65岁的受试者中，通过逐步逻辑回归分析评估超声心动图检查发现的主动脉硬化或狭窄与动脉粥样硬化临床危险因素之间的关系。
在整个研究队列中，主动脉瓣硬化的发生率为26%，主动脉瓣狭窄的发生率为2%；在年龄≥75岁的受试者中，硬化的发生率为37%，狭窄的发生率为2.6%。与退行性主动脉瓣疾病相关的独立临床因素包括年龄（每增加10岁风险增加一倍）、男性（风险高出两倍）、当前吸烟（风险增加35%）和高血压病史（风险增加20%）。其他重要因素包括身高、高脂蛋白(a)和低密度脂蛋白胆固醇水平。
与主动脉硬化和狭窄相关的临床因素可以被识别，且与动脉粥样硬化的危险因素相似。
