Mohanakrishnan P, Fowler A H, Vonsattel J P, Jolles P R, Husain M M, Liem P, Myers L, Komoroski R A
Department of Radiology, University of Arkansas for Medical Sciences, Little Rock.
J Gerontol A Biol Sci Med Sci. 1997 Mar;52(2):B111-7. doi: 10.1093/gerona/52a.2.b111.
The concentrations of selected metabolites in the hippocampus and cerebellum of 13 Alzheimer's diseased (AD) and four nondemented postmortem brains were measured using high resolution 1H NMR spectroscopy. For both the hippocampal region and the cerebellum, the putative neuronal marker N-acetyl aspartate (NAA) was significantly lower in AD brains relative to the nondemented brains. For the hippocampal region, the NAA concentration correlated inversely with semiquantitative assessments of neuronal loss and neurofibrillary tangles. The gamma-aminobutyric acid levels in both hippocampus and cerebellum of an age- and a postmortem interval-matched subset of AD brains were lower than those of the controls. Because the cerebellum is generally thought to be unaffected by AD, the NAA decrease in the Alzheimer cerebellum may be due to lesions of either the Alzheimer or non-Alzheimer type in contralateral cerebrum.
利用高分辨率1H核磁共振波谱法测定了13例阿尔茨海默病（AD）患者和4例非痴呆症死者海马体和小脑内选定代谢物的浓度。对于海马体区域和小脑，相对于非痴呆症大脑，AD大脑中假定的神经元标志物N-乙酰天门冬氨酸（NAA）显著降低。对于海马体区域，NAA浓度与神经元丢失和神经原纤维缠结的半定量评估呈负相关。在年龄和死后间隔相匹配的AD大脑子集中，海马体和小脑内的γ-氨基丁酸水平均低于对照组。由于一般认为小脑不受AD影响，阿尔茨海默病小脑内NAA的减少可能是由于对侧大脑中阿尔茨海默病或非阿尔茨海默病类型的病变所致。
