Mohanakrishnan P, Fowler A H, Vonsattel J P, Husain M M, Jolles P R, Liem P, Komoroski R A
Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA.
Exp Brain Res. 1995;102(3):503-10. doi: 10.1007/BF00230654.
The concentrations of selected metabolites in the posterior temporoparietal cortex of 13 Alzheimer's diseased (AD) and four nondemented postmortem brains (of individuals between the ages of 63 and 95) were determined using high-resolution 1H nuclear magnetic resonance (NMR) spectroscopy. The estimates for glutamate and inositol for AD brains did not show any statistically significant difference (P > 0.05) from those for the nondemented brains. The putative neuronal marker N-acetyl aspartate (NAA), creatine, and GABA were decreased in AD brains compared with the nondemented brains. The estimates for creatine, glutamate, and GABA showed significant linear correlations with those of NAA. Creatine, glutamate, GABA, and NAA appeared to be negatively correlated with the neurofibrillary tangles. Our results support a neuronal loss in the posterior temporoparietal cortices of AD brains.
使用高分辨率氢核磁共振（NMR）光谱法测定了13例阿尔茨海默病（AD）患者及4例非痴呆症死者（年龄在63至95岁之间）大脑后颞顶叶皮质中选定代谢物的浓度。AD患者大脑中谷氨酸和肌醇的测定值与非痴呆症患者大脑相比，未显示出任何统计学上的显著差异（P>0.05）。与非痴呆症患者大脑相比，AD患者大脑中假定的神经元标志物N-乙酰天门冬氨酸（NAA）、肌酸和γ-氨基丁酸（GABA）减少。肌酸、谷氨酸和GABA的测定值与NAA的测定值呈显著线性相关。肌酸、谷氨酸、GABA和NAA似乎与神经原纤维缠结呈负相关。我们的结果支持AD患者大脑后颞顶叶皮质存在神经元丢失。
