Dao-Castellana M H, Paillère-Martinot M L, Hantraye P, Attar-Lévy D, Rémy P, Crouzel C, Artiges E, Féline A, Syrota A, Martinot J L
Service Hospitalier Frédéric Joliot, CEA, INSERM U 334, Orsay, France.
Schizophr Res. 1997 Feb 7;23(2):167-74. doi: 10.1016/S0920-9964(96)00102-8.
The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p < 0.01) and in the putamen (p < 0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.
精神分裂症的多巴胺能假说假定大脑多巴胺能活性增加。此前两项研究报告称，通过正电子发射断层扫描发现精神分裂症患者（分别为n = 5和n = 7）的18F - DOPA摄取增加。在本研究中，对6名未经治疗的精神分裂症患者和7名年龄及性别匹配的对照受试者的纹状体多巴胺能功能进行了体内评估。使用配准的正电子发射断层扫描和磁共振成像测定了尾状核和壳核中的18F - 氟 - L - 多巴（18F - DOPA）摄取速率常数Ki。未发现两组间平均Ki存在差异。与对照受试者相比，精神分裂症患者尾状核（p < 0.01）和壳核（p < 0.001）中18F - DOPA摄取值的变异性更高，这表明精神分裂症是一种涉及纹状体突触前多巴胺能功能异质性状态的疾病。
