Leard A, Addy M
Division of Restorative Dentistry, Dental School, Bristol, England.
J Clin Periodontol. 1997 Feb;24(2):115-8. doi: 10.1111/j.1600-051x.1997.tb00476.x.
Dental staining is a well known and probably the most problematic side effect of using chlorhexidine oral products. Whatever mechanisms are involved, there is no doubt that cationic antiseptics, such as chlorhexidine, can precipitate or bind to surfaces anionic chromogens contained in foods and beverages. The aim of this study in vitro was to determine whether, under controlled conditions, different brands of tea or coffee varied in their propensity to cause staining associated with chlorhexidine. Optically clear acrylic specimens were cycled through saliva, chlorhexidine and different tea and coffee solutions. Staining was measured using a spectrophotometer. After 15 cycles, it was apparent that staining varied at the extreme, both within and between the tea and coffee groups. All coffee brands produced less staining than the tea brands. The least staining coffee and least staining tea brands were approximately 3x less chromogenic than the most staining equivalent beverage. Previous randomised controlled clinical trials have indicated that tea and coffee contribute to dental and tongue staining associated with chlorhexidine mouthrinses. Additionally, abstinence from tea and coffee significantly reduces staining. The results of this study in vitro suggest that when abstinence is difficult, tea and coffee brands of low chromogenicity may be recommended. Clearly these data in vitro require validation in vivo.
牙齿染色是使用洗必泰口腔产品众所周知且可能是最具问题的副作用。无论涉及何种机制,毫无疑问,阳离子防腐剂,如洗必泰,会沉淀或结合到食物和饮料中所含的表面阴离子色原上。本体外研究的目的是确定在受控条件下,不同品牌的茶或咖啡与洗必泰相关的染色倾向是否存在差异。光学透明的丙烯酸标本在唾液、洗必泰和不同的茶与咖啡溶液中循环。使用分光光度计测量染色情况。经过15个循环后,很明显,无论是在茶组和咖啡组内部还是之间,染色差异都很大。所有咖啡品牌产生的染色都比茶品牌少。染色最少的咖啡品牌和染色最少的茶品牌的发色性比染色最多的同类饮料大约低3倍。先前的随机对照临床试验表明,茶和咖啡会导致与洗必泰漱口水相关的牙齿和舌头染色。此外,不喝茶和咖啡可显著减少染色。本体外研究结果表明,当难以做到不饮用时,可推荐发色性低的茶和咖啡品牌。显然,这些体外数据需要在体内进行验证。