英国和爱尔兰共和国交感性眼炎的前瞻性监测。
Prospective surveillance of sympathetic ophthalmia in the UK and Republic of Ireland.
作者信息
Kilmartin D J, Dick A D, Forrester J V
机构信息
Department of Ophthalmology, University of Aberdeen Medical School, Foresterhill, Aberdeen AB25 2ZD, UK.
出版信息
Br J Ophthalmol. 2000 Mar;84(3):259-63. doi: 10.1136/bjo.84.3.259.
AIMS
To establish current epidemiological data, risks, and interventional outcomes of newly diagnosed sympathetic ophthalmia (SO).
METHODS
Prospective surveillance took place of all permanently employed ophthalmologists in the UK and Republic of Ireland by a monthly reporting card through the British Ophthalmological Surveillance Unit. Case ascertainment was made of newly diagnosed SO from July 1997 and questionnaire data were returned at baseline, 6 months, and 1 year after diagnosis.
RESULTS
23 patients with newly diagnosed SO were recruited over 15 months, corresponding to a minimum estimated incidence of 0.03/100 000. Baseline data were available on 18 patients, in whom SO occurred after surgery in 11 patients, after retinal surgery alone in six patients, and after accidental trauma in seven patients. 12 of the 16 patients with 1 year follow up had a visual acuity of 6/12 or better. Good visual outcome was related to prompt and adequate systemic immunosuppressive therapy.
CONCLUSIONS
The incidence of sympathetic ophthalmia is very low. The main current risk is surgery, particularly retinal surgery, but visual prognosis is good if early diagnosis is made and rapid, adequate immunotherapy is commenced.
目的
建立新诊断的交感性眼炎（SO）的当前流行病学数据、风险及干预结果。
方法
通过英国眼科监测单位每月发放的报告卡，对英国和爱尔兰共和国所有长期任职的眼科医生进行前瞻性监测。确定1997年7月以来新诊断的SO病例，并在诊断后的基线、6个月和1年时返回问卷数据。
结果
在15个月内招募了23例新诊断的SO患者，最低估计发病率为0.03/10万。18例患者有基线数据，其中11例患者的SO发生在手术后，6例仅发生在视网膜手术后，7例发生在意外创伤后。16例随访1年的患者中，12例视力为6/12或更好。良好的视力结果与及时、充分的全身免疫抑制治疗有关。
结论
交感性眼炎的发病率非常低。当前的主要风险是手术，尤其是视网膜手术，但如果能早期诊断并迅速开始充分的免疫治疗，视力预后良好。
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