来自线叶白酒草的平滑肌松弛类黄酮和萜类化合物。

Smooth muscle relaxing flavonoids and terpenoids from Conyza filaginoides.

作者信息

Mata R, Rojas A, Acevedo L, Estrada S, Calzada F, Rojas I, Bye R, Linares E

机构信息

Departamento de Farmacia, Facultad de Química and Unidad de Investigación en Plantas Medicinales, Instituto de Química, México D.F.

出版信息

Planta Med. 1997 Feb;63(1):31-5. doi: 10.1055/s-2006-957598.

DOI:10.1055/s-2006-957598

PMID:9063094

Abstract

Activity-guided fractionation of the smooth muscle relaxing, chloroform-methanol (1:1) extract of Conyza filaginoides (D.C.) Hieron (Asteraceae) led to the isolation of three flavonoids (quercetin 3-glucoside, rutin, and pinostrobin), one sterol (alpha-spinasterol), a sesquiterpenoid (beta-caryophyllene 4,5-alpha-oxide), and two triterpenoids (erythrodiol and 3-beta-tridecanoyloxy-28-hydroxyolean-12-ene). 3-beta-Tridecanoyloxy-28-hydroxy-olean-12-ene is a new naturally occurring terpenoid. All the isolated compounds induced a concentration-dependent inhibition of the spontaneous contractions of rat ileum. The spasmolytic activity exhibited by the extract and active principles tends to support the traditional use of C filaginoides as an antispasmodic agent.

摘要

对丝状白酒草（菊科）平滑肌松弛的氯仿 - 甲醇（1:1）提取物进行活性导向分级分离，得到了三种黄酮类化合物（槲皮素3 - 葡萄糖苷、芦丁和松属素）、一种甾醇（α - 菠菜甾醇）、一种倍半萜（β - 石竹烯4,5 - α - 氧化物）以及两种三萜类化合物（羽扇豆醇和3 - β - 十三烷酰氧基 - 28 - 羟基齐墩果 - 12 - 烯）。3 - β - 十三烷酰氧基 - 28 - 羟基齐墩果 - 12 - 烯是一种新的天然存在的萜类化合物。所有分离出的化合物均对大鼠回肠的自发收缩产生浓度依赖性抑制作用。提取物和活性成分所表现出的解痉活性倾向于支持丝状白酒草作为解痉剂的传统用途。