来自南艾蒿的解痉黄酮醇。
Spasmolytic flavonols from Artemisia abrotanum.
作者信息
Bergendorff O, Sterner O
出版信息
Planta Med. 1995 Aug;61(4):370-1. doi: 10.1055/s-2006-958106.
PMID:7480189
Abstract
Four flavonols with spasmolytic activity have been isolated from a methanol extract of Artemisia abrotanum L. (Asteraceae), as the principles primarily responsible for the smooth muscle relaxing activity of this plant. The flavonols show a dose-dependent relaxing effect on the carbacholine-induced contraction of guinea-pig trachea, the EC50 values for compounds 1-3 are 20-30 mumol/l while compound 4 is less active.
摘要
从南艾蒿（菊科）的甲醇提取物中分离出了四种具有解痉活性的黄酮醇，它们是该植物平滑肌舒张活性的主要成分。这些黄酮醇对豚鼠气管由卡巴胆碱诱导的收缩呈现剂量依赖性的舒张作用，化合物1 - 3的EC50值为20 - 30 μmol/L，而化合物4的活性较低。
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