Shabalina L P, Krillov V F, Spiridonova V S, Poliakova M M, Popova O L, Shamshinova A M
Med Tr Prom Ekol. 1996(10):25-30.
Absence of early signs specific for thallium intoxication requires objective diagnostic methods. The studies covered 4 techniques: electroretinography (ERG), assessment of urine levels of thallium and delta-aminolevulinic acid, capillaroscopy. The authors supported their previous foundation concerning diagnostic value of ERG for early diagnosis of thallium effects (higher amplitude of b-wave in one and that of a-wave in 8 out of 10 examinees). Further experimental and clinical basis for grading the intoxication through amounts of urinary thallium were found promising. Capillaroscopy method appeared informative: 8 out of 12 examinees demonstrated spastic and atonic state of hand capillaries--that provided objective verification of vascular disorders in workers exposed to thallium and its derivatives.
铊中毒早期特异性体征的缺失需要客观的诊断方法。研究涵盖了4种技术：视网膜电图（ERG）、铊和δ-氨基乙酰丙酸尿液水平评估、毛细血管镜检查。作者支持他们之前关于ERG对铊中毒早期诊断的诊断价值的依据（10名受检者中有1名b波振幅升高，8名a波振幅升高）。通过尿铊含量对中毒程度进行分级的进一步实验和临床依据很有前景。毛细血管镜检查方法显示出信息量较大：12名受检者中有8名表现出手部毛细血管的痉挛和张力缺失状态——这为接触铊及其衍生物的工人血管疾病提供了客观验证。
