Arnedo Pena A, Bellido Blasco J B, Pac Sa M R, González Morán F, Criado Juárez J, Mesanza del Notario I, Rodríguez Merquero N, Balagué López A
Sección de Epidemiología, Dirección Territorial Sanidad y Consumo, Castellón.
Med Clin (Barc). 1996 Nov 16;107(17):645-8.
To investigate and control of a collective scombroid-fish poisoning (SFP) outbreak, that took place in Castellón, Spain.
Description of the outbreak and case-control study in order to identify risk factors. Active surveillance of SFP cases, and inspection of implicated markets. Histamine determination in urine of cases and foods.
During June 1994, 15 cases of SFP were found out, with 12 cases occurred on June, 28 and 29. Five families were affected (attack rate 68.2%). The median incubation period was 45 minutes. Disease symptoms included facial or general flushing, headache, diarrhea, nausea, abdominal pain, and peppery taste. Implicated food was fresh tuna, bought in a hypermarket of Castellón (odds ratio = 26.4, 95% confidence intervals: 1.05-666.8), adjusted by age and sex using logistic regression analysis. Four samples of urine from cases presented histamine concentration above 35 micrograms/l. Three samples of tuna consumed by cases and one sample of tuna from the hypermarket had histamine concentration above a 200 ppm. Considering the situation of risk, remaining suspected tuna was confiscated from the hypermarket. Rest unknown if the descompositions of tuna occurred in the hypermarket or during capture and distribution.
SFP was caused by fresh tuna ingestion with epidemiologic and analytic confirmation. Determination of histamine in urine of patients could permit to confirm SFP.
调查并控制在西班牙卡斯特利翁发生的一起集体鲭鱼中毒（SFP）事件。
描述该事件并进行病例对照研究以确定风险因素。对SFP病例进行主动监测，并检查相关市场。测定病例尿液和食品中的组胺含量。
1994年6月期间，发现15例SFP病例，其中12例发生在6月28日和29日。5个家庭受到影响（罹患率68.2%）。中位潜伏期为45分钟。疾病症状包括面部或全身潮红、头痛、腹泻、恶心、腹痛和胡椒味。涉事食品为在卡斯特利翁一家超市购买的新鲜金枪鱼（优势比=26.4，95%置信区间：1.05-666.8），采用逻辑回归分析按年龄和性别进行校正。4例病例的尿液样本组胺浓度高于35微克/升。病例食用的3份金枪鱼样本以及超市的1份金枪鱼样本组胺浓度高于200 ppm。考虑到风险情况，从超市没收了剩余的可疑金枪鱼。尚不清楚金枪鱼的分解是发生在超市内还是在捕捞和分销过程中。
经流行病学和分析确认，SFP是由食用新鲜金枪鱼引起的。测定患者尿液中的组胺可确诊SFP。
