[儿童上、下尿路感染中N-乙酰-β-葡萄糖苷酶的评估。168例儿童的临床研究]
[Evaluation of N-acetyl-beta glucosaminidase in upper and lower urinary tract infections in childhood. Clinical study of 168 children].
作者信息
Belli A, Scalercio F, Martino F, Guido F, Aprigliano D, Lorusso G, Mannarino O, Ruberto U
机构信息
Istituto di Clinica Pediatrica, Università degli Studi di Roma, La Sapienza, Roma.
出版信息
Minerva Pediatr. 1996 Nov;48(11):503-7.
BACKGROUND
Urinary N-acetyl-beta-glucosaminidase (NAG) is a renal tubular enzyme that may be used as a marker of tubular damage.
METHODS
We studied 96 patients 1 to 8 years old and considered NAG excretion to distinguish cystitis from pyelonephritis. Whenever urinary NAG values were expressed in relation to urinary creatinine concentration and compared with urinary NAG values in 72 normal controls 1 to 14 years old grouped by age.
RESULTS
Our results demonstrate that urinary NAG levels are elevated in children with pyelonephritis in the presence or absence of urinary tract abnormality.
CONCLUSIONS
Therefore, we conclude that NAG may be considered as a further criteria in the diagnosis of upper urinary tract infection and interstitial tubular damage.
背景
尿N-乙酰-β-葡萄糖苷酶（NAG）是一种肾小管酶，可作为肾小管损伤的标志物。
方法
我们研究了96例1至8岁的患者，并通过NAG排泄情况来区分膀胱炎和肾盂肾炎。每当尿NAG值与尿肌酐浓度相关并与72例1至14岁按年龄分组的正常对照者的尿NAG值进行比较时。
结果
我们的结果表明，无论是否存在尿路异常，肾盂肾炎患儿的尿NAG水平都会升高。
结论
因此，我们得出结论，NAG可被视为诊断上尿路感染和间质性肾小管损伤的进一步标准。
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