Civitelli S, Civitelli B, Landini T, Pacchiarotti M C, Mancini A, Tanzini G
Istituto di Clinica Chirurgica, Università degli Studi, Siena.
Minerva Chir. 1996 Dec;51(12):1089-94.
An increased risk of colorectal cancer has been reported in first-degree relatives of affected patients, and following cholecystectomy or partial gastrectomy for benign peptic ulcer disease. The aim of this study was to examine the incidence of these potential risk factors in 197 patients (127 males, 70 females, mean age 70 years +/- 10.9, range 22-94 years) with cancer of the large bowel and 202 controls (91 males, 111 females, mean age 68 years +/- 14.06, range 17-93 years) who underwent a total colonoscopy, that revealed no colorectal neoplasms. No significant differences were found between the case and control group for a past history of cholecystectomy or gastric surgery, respectively reported by 14 and 12 patients of group 1 and 18 and 8 patients of group 2. Patients with large bowel cancer show a significant excess of both colorectal (21.31% vs 11.9%) and extracolonic malignancies (46.19% vs 26.73) in first degree relatives (p < 0.05). In approximately 7% of them the aggregation of two or more colorectal cancers among relatives is suggestive for a hereditary form of large bowel cancer.
据报道，结直肠癌患者的一级亲属患癌风险增加，以及因良性消化性溃疡疾病接受胆囊切除术或部分胃切除术后患癌风险也会增加。本研究的目的是调查197例（127例男性，70例女性，平均年龄70岁±10.9岁，范围22 - 94岁）患有大肠癌的患者和202例对照者（91例男性，111例女性，平均年龄68岁±14.06岁，范围17 - 93岁）中这些潜在风险因素的发生率，这些对照者接受了全结肠镜检查，结果显示无结直肠肿瘤。在病例组和对照组之间，分别有1组的14例和12例患者以及2组的18例和8例患者报告有胆囊切除术或胃手术史，未发现显著差异。大肠癌患者的一级亲属中结直肠癌（21.31%对11.9%）和结肠外恶性肿瘤（46.19%对26.73）的发生率均显著更高（p < 0.05）。其中约7%的患者亲属中两种或更多种结直肠癌聚集提示为遗传性大肠癌。
