Borgesen S E, Sorensen S C, Olesen J, Gjerris F
Acta Neurol Scand. 1977 Sep;56(3):263-8.
Two cases of increased intracranial pressure associated with lumbar intraspinal tumours are reported. On the basis of protein investigations and constant flow infusion manometric tests, the pathophysiology of the increased intracranial pressure is discussed. It is demonstrated that protein macromolecules leak from the tumour into the cerebrospinal fluid and suggested that these are responsible for mechanical obstruction of the outflow channels for the cerebrospinal fluid.
报告了两例与腰椎椎管内肿瘤相关的颅内压升高病例。基于蛋白质研究和恒流灌注测压试验，对颅内压升高的病理生理学进行了讨论。结果表明，蛋白质大分子从肿瘤渗漏到脑脊液中，并提示这些蛋白质是脑脊液流出通道机械性梗阻的原因。
